Reaction to Manny Ramirez's 50-game suspension

"When people make the game look as easy as some guys do, it doesn't surprise me to learn they're having a little help because it's not an easy game. It's tough." - Houston Astros slugger Lance Berkman.

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"I think the fans come to the game, whatever sport it is and they want their team to win. I don't think they're thinking about those things. ... I think they're interested in their team winning. In any sport, not just baseball. So quote me on that. It's not just baseball. When fans go to the park and they're cheering for their team, they're not standing up there in the seventh inning, in my opinion, thinking about whether a guy did something. I don't believe that happens." - Detroit Tigers manager Jim Leyland.

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"Because you love the game, you never want to have someone taint the game or try to get an advantage by not doing things the right way. It's definitely bad, but hopefully baseball will get through it because it's a great sport." - NBA MVP LeBron James of the Cleveland Cavaliers.

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"In terms of high-profile cases, this shows baseball is getting more serious in terms of the testing program and that's a good thing. ... Also, it is regrettable that the sport does not identify substances involved in positive cases. Baseball needs to be transparent." - WADA director general David Howman.

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"I hope you never hear me be accusational toward anybody because I know for a fact that some of these things with guys being suspended at the major league or minor league level are innocent as it gets. Of course, some of them are not, but I'm not the judge in this case." - Royals manager Trey Hillman.

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"My reaction to Manny is not an isolated reaction. It's the same reaction I've had to all these guys: I think it's fraud. You enter a deal with a certain understanding, a certain expectation of past performance and a projection of future performance. If I enter into a deal with a player with those assumptions, it's incumbent upon them to be aboveboard on everything. And if they're not, I think it's fraud." - White Sox general manager Ken Williams.

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"When he was young, I definitely don't think he was on steroids. ... In some ways I'm sad about it because I had him when he was young. He's a great talent. I look at Manny Ramirez like my son. I'll wait to see exactly what it's all about." - Phillies manager Charlie Manuel, who managed and coached Ramirez in the minors and from 1994-2000 with the Cleveland Indians.

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"Obviously it hurts me deeply. No. 1, I'm a huge fan, that's for sure. So I think it's just sad news for the game, no doubt about it. It's just something that, you know, when I had Sega Genesis I used to be him. It's just one of those things. What can we say? It's definitely bad news, bad news - and bad news is never welcome." - Major league home run leader Carlos Pena of the Tampa Bay Rays.

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"This is something regrettable because Manny is one of my favorite players and I thought his numbers, his average, his home runs and RBIs where clean," - Hall of Fame pitcher Juan Marichal.

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"If a player does something now, it's pretty much a 100-percent chance you are going to get caught. The system is good now. We are where we want to be in that." - Florida Marlins infielder Wes Helms.

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"It's too bad. He's one of the star players. Nothing surprises me anymore. Unfortunate." - Atlanta Braves manager Bobby Cox.

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"It is a surprise to me. You're getting tested, so stay clean. That's a simple statement. It's probably more difficult for the team, more difficult for the Dodgers. They have to go through 50 games without somebody that they've relied upon to be the main guy in their lineup. You're making $24 million and you lose one-third of your salary, you're still making $16 million, but 50 games could cost the Dodgers a whole lot more than that." - Milwaukee Brewers manager Ken Macha.

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"Manny, with or without performance enhancing, is a Hall of Famer." - San Francisco Giants pitcher Barry Zito.