| DATE | PLAYER | DESCRIPTION |
| 05/22/2012 | Ryan Sweeney | Placed on 7-day disabled list |
|
05/22/2012 | Cody Ross | Placed on 15-day disabled list |
|
05/22/2012 | Daisuke Matsuzaka | Transferred to 60-day disabled list |
|
05/22/2012 | Scott Podsednik | Contract purchased from Pawtucket (AAA) |
|
05/22/2012 | Kevin Youkilis | Activated from 15-day disabled list |
|
05/20/2012 | Che-Hsuan Lin | Recalled from Pawtucket (AAA) |
|
05/20/2012 | Mauro Gomez | Optioned to Pawtucket (AAA) |
|
05/13/2012 | Jacoby Ellsbury | Transferred to 60-day disabled list |
|
05/13/2012 | Mauro Gomez | Contract purchased from Pawtucket (AAA) |
|
05/13/2012 | Darnell McDonald | Placed on 15-day disabled list |
|
05/10/2012 | Daniel Nova | Contract purchased from Pawtucket (AAA) |
|
05/10/2012 | Clayton Mortensen | Optioned to Pawtucket (AAA) |
|
05/10/2012 | Justin Thomas | Designated for assignment |
|
05/06/2012 | Aaron Cook | Placed on 15-day disabled list |
|
05/06/2012 | Andrew Miller | Activated from 15-day disabled list |
|
05/03/2012 | Carl Crawford | Transferred to 60-day disabled list |
|
05/03/2012 | Aaron Cook | Contract purchased from Pawtucket (AAA) |
|
05/03/2012 | Jose Iglesias | Optioned to Pawtucket (AAA) |
|
05/02/2012 | Will Middlebrooks | Recalled from Pawtucket (AAA) |
|
05/02/2012 | Kevin Youkilis | Placed on 15-day disabled list |
|
05/02/2012 | Clayton Mortensen | Recalled from Pawtucket (AAA) |
|
05/02/2012 | Lars Anderson | Optioned to Pawtucket (AAA) |
|
05/01/2012 | Jose Iglesias | Recalled from Pawtucket (AAA) |
|
05/01/2012 | Junichi Tazawa | Optioned to Pawtucket (AAA) |