Who will win in this matchup of bottom-of-the-run NFL teams and what is the NFL pick?

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The performance of these two teams is in many ways similar.  They have been defeated once by a very good NFL team, and have won once against the St. Louis Rams.  Amidst quarterback troubles in this NFL free pick, it could come down to how well the Raiders run and the home-field advantage.

Oakland Raiders in NFL actionSBR odds give Arizona (-4.5) the slight nod over the Raiders (+4.5) in this NFL betting matchup.  Every sportsbook, including Pinnacle, BookMaker, and 5Dimes has this football spread.  The total is set to 39.5 points.

Top NFL Betting Action at 5Dimes.com

Oakland Raiders (+4.5) (1-1)

Don't be surprised to see the Raiders not only cover, but win in this football betting matchup.

NFL handicappers are well aware of the Raiders' difficulties, largely stemming from the quarterback position.  Jason Campbell was pulled in Week 2 at halftime for Bruce Gradkowski, who led the Raiders to a 16-14 win over St. Louis, with 13 second-half points.

After a rout at Tennessee and the close game against the Rams at home, football odds makers are banking off of Oakland's lackluster performance.  They will need a strong start with their new quarterback in Arizona.

The Cardinals notably have the second-worst rushing defense in allowing 153 yards a game on the ground.  Couple that with Oakland's third-best rushing game, and you could have the X-factor here.  RB Darren McFadden has 240 yards over 48 carries.

Top NFL Betting Action at 5Dimes.com

Arizona Cardinals (-4.5) (1-1)

The Cardinals also have difficulties at the quarterback position in this football pick.

Derek Anderson threw two interceptions last week against Atlanta in the 47-7 loss, going 17 for 31.  He has two talented receivers if he can get things going, in Steve Breaston and Larry Fitzgerald.

The Cardinals could have similar chances on the ground, with Oakland having the 29th ranked rushing defense, allowing 140 yards a game on the ground.  Tim Hightower has been efficient but not dominant, with 169 yards and two touchdowns over 24 carries (7.0 average yards per carry).

Along with the quarterback position, one of the biggest points for the Cardinals in this football betting matchup is defense.  Arizona has the second-worse rushing defense and is ranked 21st in passing defense.  They may give Gradkowski the looks he needs to cover this spread and possibly the minor upset.

Top NFL Betting Action at 5Dimes.com

Overview

Offensive inefficiencies may cast doubt on the under here, but each team's game against the Rams (17-13 Cardinals, 16, 14 Raiders) went that route in their respective NFL betting matchups.  We could have a repeat with respect to the total.

Arizona's terrible defense and quarterback inaccuracy (keep in mind, Oakland has a good passing defense) makes this a good choice to go with the points.  The Raiders should be able to cover and to possibly win the game, unless Arizona turns things around.

The Cardinals' home-field advantage could also be big.  Remember, this is the home opener - something that the NFL handicappers could be banking on in Sunday's football betting matchup.

Keep track of SBR odds to get the latest lines on this NFL pick  Also, look at other NFL betting previews on SBR to help you on Sunday.

Head to the NFL Handicapping forum at SBR to discuss this game.  It should be interesting in Arizona.